![]() In these trials, scopolamine was demonstrated to be superior to placebo for preventing motion sickness.Ĭomparisons of scopolamine and antihistamines have yielded varying results. In addition, various dosages of scopolamine were compared. 7-9 Multiple studies were conducted to compare the scopolamine transdermal patch with placebo and antihistamines (dimenhydrinate, promethazine). 5,6 Although scopolamine is available in several dosage forms, the most common form used for motion sickness is the transdermal patch.Įarly studies were conducted in healthy volunteers who participated in the Spacelab missions in the 1970s and 1980s. Additionally, it decreases gastrointestinal secretions and motility and inhibits the secretion of saliva and sweat. This agent prevents motion sickness via its anticholinergic effects. Scopolamine is one of the most commonly prescribed medications for the treatment or prevention of motion sickness. Both pharmacologic and nonpharmacologic agents are available. 3,4 Numerous treatment and prevention options for motion sickness exist, as described in TABLE 1. Additionally, motion sickness may be caused by certain medications, including but not limited to macrolides, metronidazole, morphine, digoxin, and some selective serotonin reuptake inhibitors. Patients with a history of migraines may be more likely to experience motion sickness. Women are more likely than men to experience motion sickness, especially during pregnancy or menstruation or in those taking hormone therapy. Children aged 2 to 12 years are more susceptible to the condition than those aged <2 years. Susceptibility to motion sickness varies among individuals. It can begin suddenly, with signs and symptoms including dizziness, nausea, and vomiting. 1 Motion sickness can manifest during air travel and in cars or trains, but it occurs most frequently during boat travel (seasickness). Motion sickness occurs when the motion perceived visually does not match that sensed by the brain. The brain normally receives signals from the inner ears, eyes, muscles, and joints. Motion sickness is a common occurrence for many people during travel. All agents can cause unwanted side effects and have precautions for specific patient populations. Although there are several OTC options for motion sickness, it is important for pharmacists to consider individual patient characteristics before making a recommendation. Several effective pharmacologic treatments are available, including both prescription and OTC medications. ![]() Some people are more susceptible to motion sickness than others. ABSTRACT: Motion sickness is a common malady in the general population however, the exact mechanism through which it occurs is not completely known.
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